| BoroScience
Canada, Inc was founded in 2004 by Bernard F. Spielvogel, Ph.D.
He obtained a B.S. degree in Chemistry and Physics from Geneva
College(Pennsylvania) and the Ph.D. degree in Inorganic Chemistry
from the University of Michigan. Dr Spielvogel has over 40yrs
experience in synthetic boron chemistry. He has a breadth of
experiences in academic, government and business circles. His
academic appointments include The University of North Carolina
at Chapel Hill, Duke University, North Carolina State University
at Raleigh, Northern Illinois University and Mt Allison University
in Sackville, New Brunswick. He served as a basic research grant
administrator at the Army Research Office for 20yrs. He has
founded or co-founded 5 high tech companies based upon boron
technology. His research has led to over 135 publications and
numerous patents. He is the principal inventor on patents in
the field of boron analogs of amino acids, peptides and nucleic
acids. These compounds and related boron compounds have been
found to have a wealth of biological and pharmacological activity.
A list of publications is included.
Publications
of Bernard F. Spielvogel
(137
Publications and 70 Patents and Applications)
1. B.F. Spielvogel
and E.F- Rothgery, "Intermediates in the Thiohydrolysis
of Lithium Borohydride" Chem. Comm., 765, 1966,.
2. B.F. Spielvogel,
J .M. Purser, "Correlations between Carbon-13 and Boron-11
Chemical Shifts. I. The Alkanes and Analogous Boron-Nitrogen
Compounds" Journal of the American Chemical Society,
89, 20,1967.
3. J.M. Purser
and B.F. Spielvogel, "Correlations between Carbon-13
and Boron-11 Chemical Shifts. II. Chemical Shift Parameters
for Amine Boranes and Related Compounds" Inorganic Chemistry,
7, 2156, 1968.
4. J.M. Purser
and B.F. Spielvogel, "Constitutive Chemical-Shift Parameters
for Amineboranes and Related Compounds" Chemical Communications,
page 386, 1968.
5. B.F. Spielvogel
and J.M. Purser, "Correlations between Carbon-13 and
Boron-11 Chemical Shifts. III. Pairwise Interaction Parameters"
Journal of the American Chemical Society, 93, 4418, 1971.
6. B.F. Spielvogel,
R.F. Bratton, "Cyanoborane Chemistry .I. Preparation
of a Novel Series of Macrocyclic Cyanoboranes" Journal
of American Chemical Society, 94, 8597, 1972.
7. Bernard F. Spielvogel,
"Borane" McGraw-Hill Yearbook Science Technology"
McGraw Hill Book Co., Inc. 1974.
8. Bernard F. Spielvogel,
W. Rodger Nutt, Robert A. Izydore, "Correlations between
Carbon-13 and Boron-11 Chemical Shifts. IV. Carbenium Ions
and Their Trigonal Boron Analogs" Journal of American
Chemical Society, 97, 1609, 1975.
9. B.F. Spielvogel,
* Leonard Wojnowich, Mrinal K. Das, Andrew T. McPhail, * Karl
D. Hargrave, "Boron Analogues of Amino Acids. Synthesis
and Biological Activity of Boron Analogues of Betaine"
Journal of the American Chemical Society, 98, 5702, 1976.
10. Karl D. Hargrave,
Andrew T. McPhail, * Bernard F. Spielvogel, * Patty Wisian-Neilson,
"Synthesis and Crystal Structure of Hexakis (ammonia-cyanoborane)-Sodium
Iodide" Journal of the Chemical Society, Dalton Transactions,
1977.
11. McPhail, A.
T., Onan, K.D., Spielvogel, B.F., Wisian-Neilson, P., "Synthesis
and X-Ray Crystal Structure Characterization of Ammonia-Cyanoborane"
J. Chem. Res. (5) 205, 1978, and J. Chem. Research (M) 2601-2618,
1978.
12. "Boron
Compounds May Find Therapeutic Uses" Featured in Chem.
Eng. News, 56, No. 34, 21, 1978.
13. Spielvogel,
B.F., "Synthesis of Biologically Active Boron Analogs
of Amino Acids and Related Compounds" Ventron Alembic,
Issue No.14, 1978.
14. Wisian-Neilson,
P., Das, M.K., Spielvogel, B.F., "A general Synthesis
of Amine- Cyanoboranes" Inorg. Chem., 17, 2327, 1978.
15. Hall, I.H.,
Starnes, C.O., Spielvogel, B.F., Wisian-Neilson, P., Das,
M.K., Wojnowich, L., "Boron Betaine Analogs: Antitumor
Activity and Effects on Ehrlich Ascites Tumor Cell Metabolism"
J. Pharm. Sci., 68, 685, 1979.
16. Spielvogel,
B.F., Harchelroad, Jr. F., Wisian-Neilson, P., "Synthesis
of Some Cyano-, Amido-, and Carboxyborane Adducts of Amines
and Diamines" J. of Inorg. and Nucl. Chem., 41, 1223-1227,
1979.
17. Hall, I.H.,
Starnes, C.O., McPhail, A. T., Wisian-Neilson, P., Das, M.K.,
Harchelroad, Jr. F., Spielvogel, B.F., "The Anti-Inflammatory
Activity of Amine Cyanoboranes, Amine Carboxyboranes and Related
Compounds" J. Pharm. Sci., 69, 1025, 1980.
18. Spielvogel,
B.F., McPhail, A. T., Das, M.K., Hall, I.H., "Boron Analogues
of the a- Amino Acids. Synthesis, X-Ray Crystal Structure
and Biological Activity of Ammonia- Carboxyborane, the Boron
Analogue of Glycine" J. Amer. Chem. Soc., 102, 6343,1980.
19. Spielvogel,
B.F., Parry, R.W., Kodama, G., "Synthesis and Biological
Activity of Boron Analogues of the a-Amino Acids and Related
Compounds" "Boron IV" Pergamon Press, Eds.,
119, 1980.
20. Hall, I.H.,
Das, M.K., Harchelroad, Jr. F., Wisian-Neilson, P., McPhail,
A. T., Spielvogel, B.F., "The Antihyperlipidemic Activity
of Amine Cyanoboranes, Amine Carboxyboranes and Related Compounds"
J. Pharm. Sci. 70, 339, 1981.
21. Scheller, K.H.,
Martin, R.B., Spielvogel, B.F., McPhail, A.T., "Basicity
and Metal Ion Binding Capability of Amine-Carboxyboranes,
R3N-BH2COOH, Boron Analogs of Glycine and N-Methylated Glycines"
Inorg. Chemica Acta, 57, 227, 1982.
22. Spielvogel,
B.F., McPhail, A.T., Knight, J.A., Moreland, G.C., Gatchell,
C.L., Morse, K. W., "Predictive Schemes for the Reactivity
of Borane Carbonyl and the Stability of Carbonyltrihydroborate
Anions, BH3C(O)X" Polyhedron, 2, 1345, 1983.
23. Spielvogel,
B.F., McPhail, A.T., Hall, I.H., Fairchild, R.G., Micca, P.L.,
"Boron Analogues of a-Amino Acids" Proceedings of
the First International Symposium on Neutron Capture Therapy,
DOE Report BNL 51730, October 12-14, 1983.
24. Spielvogel,
B.F., McPhail, A.T., Gross, P.M., “Biologically Active
Boron Analogs of a-Amino Acids and Derivatives”, Ventron
Alembic Issue #32, Dec., 1983.
25. Hall, I.H.,
Spielvogel, B.F., McPhail, A.T., "Antineoplastic Activity
of Tetrakis-m- (trimethylamine-boranecarboxylato)-bis(trimethylamine-carboxyborane)
dicopper(II) in Ehrlich Ascites Carcinoma" J. Pharm.
Sci., 73, 222, 1984.
26. Spielvogel,
B.F., Ahmed, F.U., Morse, K.W., McPhail, A.T., "Boron
Analogues of Amino Acids. 3. Synthesis of (Ethylcarbomoyl)
Borane Adducts of Me3N, Me2NH, MeNH2, and NH3" "Inorg.
Chem., 23, 1776, 1984.
27. Spielvogel,
B.F., Ahmed, F.U., Silvey, G.L., Wisian-Neilson, P., McPhail,
A.T., "Boron Analogues of Amino Acids. 4. Synthesis of
Glycine and N-Methylated Glycine Ester Analogues" Inorg.
Chem., 23, 4322, 1984.
28. Spielvogel,
B.F., Ahmed, F.U., Das, M.K., McPhail, A. T., "Synthesis
of Sodium and Tetra-n-Butylammonium Dicyanodihydroborates"
Inorg. Chem., 23, 3263, 1984.
29. Hall, I.H.,
Williams, W., Gilbert, C.J., McPhail, A.T., Spielvogel, B.F.,
"The Hypolipidemic Activity of Tetrakis-m-(trimethylamine-boranecarboxylato)-
bis(trimethylamine-carboxyborane) dicopper(II) in Rodents
and its Effect on Lipid Metabolism" J. Pharm. Sci., 73,
973, 1984.
30. Hall, I.H.,
Gilbert, C.J., McPhail, A.T., Morse, K.W., Hassett, K., Spielvogel,
B.F., "The Antineoplastic Activity of a Series of Boron
Analogues of a-Amino Acids" J. Pharm. Sci. 74, 755, 1985.
31. Hakemi, H.,
Ahmed, F.U., Krigbaum, W.R., McPhail, A.T., Spielvogel, B.F.,
"Investigation of Mixtures of Cholesteryl Esters of Boron
Analogues of Amino Acids with P-Azoxyanisole" Mol. Cryst.
Liq. Cryst., 128, 65, 1985.
32. Spielvogel,
B.F., Ahmed, F.U., McPhail, A.T., "Boron Analogues of
Amino Acids. 5. A Simple, Convenient Method for the Esterification
of Amine-Carboxyboranes" Synthesis, 833, 1986.
33. Spielvogel,
B.F., Ahmed, F.U., McPhail, A.T., "A Remarkably Facile
Synthesis of An Isoelectronic and Isostructural Boron Analogue
of Acetylcholine" J. Amer. Chem. Soc., 108, 3824, 1986.
34. Spielvogel,
B.F., Ahmed, F.U., McPhail, A.T., "Boron Analogues of
Choline 2. Efficient Syntheses of Boron Analogues of Choline,
Acetylcholine, and Substituted Acetylcholines" Inorg.
Chem., 25, 4395, 1986.
35. Hall, I.H.,
Spielvogel, B.F., Sood, A., Ahmed, F., Jafri, S., "Hypolipedemic
Activity of Trimethylamine-Carboxyborane and Related Derivatives
in Rodents" J. Pharm. Sci., 76, 359, 1987.
36. Spielvogel,
B.F., Hall, I.H., "Boron Analogues of Biologically Important
Molecules" Workshop Proceedings: Boron Compounds Suitable
for Neutron Capture Therapy for the Treatment of Cancer. Annapolis,
MD May 3-4, 1988. Published by National Cancer Institute,
Bethesda, MD.
37. Spielvogel,
B.F., "Pharmacologically Active Boron Analogues of Amino
Acids" Chapter 15, p. 329 in Advances in Boron and the
Boranes, Vol. 5, J.F. Liebman, A. Greenberg, R.E. Williams,
Eds., 1988.
38. Spielvogel,
B.F., Ahmed, F.U., McPhail, A T., "Boron Analogues of
Amino Acids" Inorganic Syntheses, H.R. Allcock, Ed.,
Vol. 25, John Wiley, 79-84, 1989.
39. Sood, A., Spielvogel,
B.F., "Boron Analogs of Amino Acids VII. Synthesis of
Ammonia- (N-Ethylcarbomoyl) Methylborane, H3NBH(CH3)C(O)NHEt,
a Boron Analogue of the N-Ethylamide of Alanine" Main
Group Metal Chemistry, 12, 143-147, 1989.
40. Sood, A., Shaw,
B.R., Spielvogel, B.F., "Boron Containing Nucleic Acids:
Synthesis of Cyanoborane Adducts of 2'-Deoxynucleosides"
J. Amer. Chem. Soc., 111, 9234, 1989.
41. Spielvogel,
B.F., Sood, A., Hall, I.H., Fairchild, R.G., Micca, P.L.,
"Synthesis, Antineoplastic Activity and Biodistribution
of Boron Analogues of Amino Acids and Related Compounds"
Strahlenther. Onkol, 165, 123-125, 1989.
42. Hall, I.H.,
Spielvogel, B.F., Griffin, T.S., Docks, E.L., Brotherton,
R.J., "The Effects of Boron Hypolipidemic Agents on LDL
and HDL Receptor Binding and Related Enzyme Activities of
Rat Hepatocytes, Aorta Cells and Human Fibroblasts" Research
Communications in Chemical Pathology and Pharmacology, 65,
297, 1989.
43. Sood, A., Sood,
C.K., Spielvogel, B.F., Hall, I.H., "Boron Analogues
of Amino Acids VI. Synthesis and characterization of Di- and
Tripeptide Analogues as Antineoplastic, Anti-Inflammatory
and Hypolipidemic Agents" European Journal of Medicinal
Chemistry, 25, 301-308, 1990.
44. Sood, A., Shaw.
B.R., Spielvogel, B.F., "Boron Containing Nucleic Acids
2. Synthesis of Oligodeoxynucleoside Boranophosphates"
J. Am. Chem. Soc., 112, 9000-9001, 1990.
45. Hall, I.H.,
Spielvogel, B.F., Sood, A., "The Antineoplastic Activity
of Trimethylamine Carboxyboranes and Related Esters and Amides
in Murine and Human Tumor Cells Lines" Anti-Cancer Drugs.
1, 133-141, 1990.
46. Spielvogel,
B.F., Sood, A., Shaw, B.R., Hall, I.H., "From Boron Analogues
of Amino Acids to Boronated DNA: Potential New Pharmaceutical
and Neutron Capture Agents" IME Boron VII Poland, August
1990, Pure and Appl. Chemistry, 63, 415-418, 1991.
47. Sood, A., Sood,
C.K., Spielvogel, B.F., Hall, I.H., Wong, O.T., Mittakanti,
M., Morse, K., "Synthesis and Hypolipidemic Activity
of Amine-Carboxyboranes and Their Amides and Esters in Rodents"
Arch. der Pharm. (Weinheim), 324, 423-432, 1991.
48. Hall, I.H.,
Morse, K. W., Spielvogel, B.F., Sood, A., "DNA Interaction
with Metal Complexes and Salts of Substituted Boranes and
Hydroborates in Murine and Human Tumor Cell Lines" Anti-Cancer
Drugs, 2, 389-399, 1991.
49. Spielvogel,
B.F., Sood, A., Morse, K.W., Wong, O.T., Hall, I.H., "The
Cytotoxicity of Amine-Cyanoboranes, Amine-Cyanoalkylboranes,
and Aminoethylphosphate Cyanoborane Adducts Against the Growth
of Murine and Human Tissue Cultured Cells" Die Pharmazie,
46, 592-594, 1991.
50. Sood, A., Sood,
C.K., Hall, I.H., Spielvogel, B.F., "Boron Analogues
Phosphonoacetates: Synthesis, Characterization and Anti- Tumor
Properties of Sodium Diethylphosphite- Carboxyborane and Related
Compounds" Tetrahedron Letters, 47, 6915-6930, 1991.
51. Hall, I.H.,
Reynolds, D.J., Chang, J., Spielvogel, B.F., Griffin, T.S.,
Docks, E.L., "Acute Toxicity of Amine-Boranes and Related
Derivatives in Mice” Arch. Pharm. (Weinheim), 324, 573-577,
1991.
52. Hall, I.H.,
Brotherton, R.I., Docks, E.L., Griffin, T.S., Sood, A., Spielvogel,
B.F., "Hypolipidemic Activity of Some Hydropolyborate
Salts in Rodents" Biomed. Biochim. Acta, 50, No.8, 1007-1017,
1991.
53. Sood, C.K.,
Sood, A., Spielvogel, B.F., Yousef, J.A.., Burham, B., Hall,
I.H., "Synthesis and Antineoplastic Activity of some
Cyano-, Carboxy-, Carbomethoxy-, and Carbamoylborane Adducts
of Heterocyclic Amines" J. Pharm. Sci., 80, No.12, 1133-
1140, 1991.
54. Hall, I.H.,
Sood, A. Spielvogel, B.F., "The Hypolipidemic Activity
of Heterocyclic Amine Boranes in Rodents" Biomed &
Pharmacother, 45, 333-341 1991.
55. Burnham, B.S.,
Wyrick, S.D., Hall, I.H., Sood, A., Spielvogel; B.F., "Synthesis
of [2-14C]-2'-Deoxycytidine-3N-Cyanoborane" J. of Labelled
Compounds and Radiopharmaceuticals, 29; No.4, 469-473, 1991.
56. Sood, A., Spielvogel,
B.F., "A New and Convenient Synthesis of Sodium Carboxylatotrihydroborate,
Na2BH3C02; a Boron Analog of Sodium Acetate" Inorg. Chem.,
31, 2654-2655, 1992.
57. Sood, A., Spielvogel,
B.F., Shaw, B.R., Carlton, L.D., Bumham, B.S., Hall, E.S.,
Hall, I.H., " The Synthesis and Antineoplastic Activity
of 2'-Deoxynucleoside-Cyanoboranes in Murine and Human Culture
Cells" Anticancer Research, 12, 335-344, 1992.
58. Miller, M.C.
III, Wyrick, S.D., Hall, I.H., Sood, A., Spielvogel, B.F.,
"Synthesis of [14C]-N-[{trimethylamineboryl) carbonyl]
Phenylalanine-Methyl Ester" J. of Labelled Compounds
and Radiopharmaceutica1s, 31, 595, 1992.
59. Spielvogel,
B.F., Sood, A., Shaw, B.R., Hall, I.H., Fairchild, R.G., Laster,
B.H., Gordon, C., "Boron Containing Nucleic Acids"
Progress in Neutron Capture Therapy for Cancer, Sidney, Australia,
Dec 4-7, 1990, 211-213, 1992.
60. Sood, A., Sood,
C.K., Spielvogel, B.F., Hall, I.H., Wong, O.T., "Synthesis,
Cytotoxicity, Hypolipidemic and Anti-Inflammatory Activities
of Amine-Boranes and Esters of Boron Analogues of Choline
and Thiocholine" J. of Pharm, Sci., 81, No.5, 458-462,
1992.
61. Hall, I.H.,
Wong, O.T., Sood, A., Sood, C.K., Spielvogel, B.F., Shrewsbury,
R.P., Morse, K. W., "Hypolipidaemic Activity in Rodents
of Boron Analogs of Phosphonacetates and Cyanoborane Adducts
of Dialkyl Aminomethylphosphonates" Pharmacol. Res. Commun.,
25, 259-270, 1992.
62. Hall, I.H.,
Hall, E.S., Chi, L.K., Miller, M.C. III, Bastow, K.F., Sood,
A., Spielvogel, B.F., "The Anti-Neoplastic Activity of
Ethylaminecarboxyborane and Triphenylphosphine-Carboxyborane
in L-1210 Lymphoid Leukemia Cells" Applied OrganoMetallic
Chemistry, 6, 229-239, 1992.
63. Hall, I.H.,
Hall, E.S., Chi, L.K., Shaw, B.R., Sood, A., Spielvogel, B.F.,
"Antineoplastic Activity of Boron Containing Thymidine
Nucleosides in Tmolt3 Leukemic Cells" Anti- Cancer Res.,
12, 1091-1098, 1992.
64. Sood, A., Spielvogel,
B.F., Shaw, B.R, Hall, E.S., Chi, L.K., Hall, I.H., "The
Synthesis and Anti-Neoplastic Activity of 2-N-Isobutyryl-2'Deoxyguanosine-N7-cyanoborane
Derivatives" der Pharmazie, .47, 833-838, 1992.
65. Hall, I.H.,
Spielvogel, B.F., Morse, K.W., "Amine-Borane Derivatives
as Antineoplastic Agents" Metal-Based Antitumor Drugs,
Vo1 2, 55, 1992.
66. Tomasz, V.,
Shaw, B.R., Porter, K., Spielvogel, B.F., Sood, A., "5'-P-Borane-Substituted
Thymidine Monophosphate and Triphosphate" Angew. Chem.
Int. Engl., 31, 1373, 1992.
67. Hall, I.H.,
Burnham, B.S., Rajendran, K.G., Chen, S.Y., Sood, A., Spielvogel,
B.F., Shaw, B.R., "Hypolipidemic Activity of Boronated
Nucleosides & Nucleotides in Rodents" Biomed. Pharmacotherapy,
47, 79-87, 1993.
68. Hall, I.H.,
Hall, E.S., Miller, M.C. III, Sood, A., Spielvogel, B.F.,
"The Effects of Boron Containing Peptides on L-1210 Lymphoid
Leukemia Metabolism" Amino Acids, 4, 287- 302, 1993.
69. Bumham, B.S.,
Hall, I.H., Shrewsbury, R.P., Hall, E.S., Sood, A., Spielvogel,
B.F., "Disposition and Distribution of the Cytidine-Cyanoborane
Adduct of [2- 14C]-2'- Deoxycytidine-3N-Cyanoborane in CF1
Mice" Drug Investigations, 6, 75-82, 1993.
70. Spielvogel,
B.F., Sood, A., Tomasz, J., Shaw, B.R., Karthikeyan, S., Powell,
W., Laster, B., Brugger, RM., Coderre, J., "Boronated
Peptides and Nucleic Acid Components for NCT” Advances
in Neutron Capture Therapy, A.H., Soloway, et. al., Ed. Plenum
Press, N. Y., 361, 1993, 75-82, 1993.
71. Spielvogel,
B.F., Sood, A., Powell, W., Tomasz, J., Porter, K., Shaw,
B.R., "Chemical and Enzymatic Incorporation of Boron
into DNA" Advances in Neutron Capture Therapy, A.H. Soloway,
et. al., Ed. Plenum Press, N. Y., 389, 1993.
72. Shaw, B.R.,
Madison, J., Sood, A., Spielvogel, B.F., “Oligonucleoside
Boranophosphate (Borane Phosphate)”, Methods in Molecular
Biology, Vol. 20, Edited by S. Agrawal, Humana Press Inc.,
225-243, 1993.
73. Spielvogel,
B.F., "Boron Analogues of Biomolecules: Biomedical Prospects"
Phosphorus, Sulfur, and Silicon, 87, 267, 1994.
74. Hall, I.H.,
Chen, S.Y., Rajendran, K.G., Sood, A., Spielvogel, B.F., Shih,
J., "Hypolipidemic, Anti-Obesity, Anti-Inflammatory,
Anti-Osteoporotic, and Anti- Neoplastic Properties of Amine
Carboxyboranes" Environmental Health Perspectives, 102,
Suppl.3, 21-30, 1994.
75. Hall, I.H.,
Burnham, B.S., Hall, E.S., Sood, A., Spielvogel, B.F., "An
Investigation of 2'Deoxyribonucleoside Cyanoboranes for Acute
Toxicity in Mice” Metal Based Drugs, 1-30, 1994.
76. Hall, I.H.,
Rajendran, K.G., Chen, S.Y., Norwood, V.N. III, Morse, K.W.,
Sood, A., Spielvogel, B.F., "The Anti-inflammatory Activity
of Metal Complexes and Salts of Amine Carboxvboranes"
Applied Organometallic Chemistry, 8, 473-480, 1994.
77. Rajendran,
K.G., Burnham, B.S., Chen, S.Y., Sood, A., Spielvogel, B.F.,
Shaw, B.R., Hall, I.H., "The Anti-Inflammatory and Anti-Osteoporotic
Activities of Base-Boronated Nucleosides and Phosphate-Boronated
Nucleotide in Rodents" J. Pharm. Sci., 83, 1391- 1395,
1994.
78. Sood, A., Spielvogel,
B.F., Powell, W.J., Bastow, K.F., Miller, M.C. III, Hall,
I.H., "Cytotoxicity of Ribo- and Arabinoside Boron Nucleosides
in Tissue Culture Cells" Anticancer Res., 14, 1483-1488,
1994.
79. Burnham, B.S.,
Chen, S.Y., Rajendran, K.G., Sood, A, Spielvogel, B.F., Shaw,
B.R., Hall, I.H., "The Synthesis of Amine-Borane Adducts
of Cyclohexylamine Toluidine, and 3'-Aminodideoxynucleosides
and Evaluation of Their Pharmacological Activity" Current
Topics in Chemistry of Boron, Royal Society of Chemistry,
189-192, 1994.
80. Spielvogel,
B.F., Sood, A., Shaw, B.R., Hall, I.H., "Synthesis of
Boron Analogues of Biomolecules as Potential New Pharmaceuticals"
Current Topics in Chemistry of Boron, Royal Society of Chemistry,
193-190, 1994.
81. Spielvogel,
B.F., "Choose a New Path: Boron Biologicals" Biotechnology
in the Feed Industry, T.P. Lyons and K.A. Jackes, Eds. Nottingham
University Press, Leicestershire, England, 303, 1994.
82. Hall, I.H.,
Spielvogel, B.F., Sood, A., Morse, K.W., Norwood, V.M. III,
Wong, O.T., "The Hypolipidemic Activity of Metal Complexes
of Amine-Carboxyboranes in Rodents" Metal Based Drugs,
1, 329-336, 1994.
83. Hall, I.H.,
Burnham, B.S., Rajendran, K.G., Chang, J.J., Sood, A., Spielvogel,
B.F., "An Investigation of 2'-Deoxyribonucleoside Cyanoboranes
in Mice for Therapeutic Safety" Metal Based Drugs, 1,
19-30, 1994.
84. Hall, I.H,
Rajendran, K.G., Shen, S.Y., Wong, O.T., Sood, A., Spielvogel,
B.F., "The Anti-Inflammatory Activity of Amine-Carboxyboranes
in Rodents" Arch. Pharm. (Weinheim), 328, 39-.44, 1995.
85. Rajendran,
K.G., Sood, A., Spielvogel, B.F., Hall, I.H., Norwood, V.M.
III, Morse, K.W., "Anti-Osteoporotic Activity of Metal
Complexes of Amine-Carboxyboranes" Applied OrganoMetallic
Chemistry, 9, 111-119, 1995.
86. Rajendran,
K.G., Chen, S.Y., Sood, A., Spielbogel, B.F., Hall, I.H.,
"The Anti- Osteoporotic Activity of Amine-Carboxyboranes
in Rodents" Biomed & Pharmacother, 49, 131-140, 1995.
87. Burnham, B.S.,
Sood, A., Chen, S. Y., Spielvogel, B.F., Miller, M.C. III,
Hall, I.H., "The Cytotoxicity Activity of 3'-Aminocyanoborane-2',3'-Dideoxypyrimidines
in Murine and Human Tissue Cultured Cells" Anticancer
Res., 15, 951-958, 1995.
88. Burham, B.S.,
Chen, S. Y., Sood, A., Spielvogel, B.F., Hall, I.H., "Hypolipidemic
Activity of Amine-Borane Adducts of Cyclohexylamine and Toluidine
in Rodents" Metal Based Drugs, 2, 221-232, 1995.
89. Burnham, B.S.,
Chen, S. Y., Sood, A., Spielvogel, B.F., Hall, I.H., "Synthesis
and Cytotoxicity of Amine-Borane Adducts of Cyclohexylamines
and Toluidines" Pharmazie, 50, 779- 783, 1995.
90. Miller, M.C.
III, Shrewsbury, R.P., Elkins, A.L., Sood, A., Spielvogel,
B.F., Hall, I.H., "The Disposition, Tissue Distribution,
and Cellular Transport of N- [(Trimethylamine)boryl]-L-Phenylalanine
Methyl Ester in CF1 Mice" J. Pharm, Sciences, 84, 933-936,
1995.
91. Murphy, M.E.,
Shrewsbury, R.P., Sood, A., Spielvogel, B.F., Elkins, A.L.,
Hall, I.H., "The Relationship Between Cytokine Regulation
and Anti-Inflammatory Action of Amine-Carboxyborane in L929
Fibroblasts and ICf-21 Macrophages" Metal Based Drugs,
2, 257-269, 1995.
92. Elkins, A.L.,
Eley, I.G., Miller, M.C. III, Hall, I.H., Sood, A., Spielvogel,
B.F., "Transepithelial Transport and Metabolism of Boronated
Dipeptides Across Caco-2 and HCT-8 Cell Monolayers" Metal
Based Drugs, 3, 277-286, 1996.
93. Hall, I.H.,
Burnham, B.S., Chen, S.Y., Sood, A., Spielvogel, B.F., Morse,
K.W., "The Anti-Inflammatory Activity of Boron Derivatives
in Rodents" Metal Based Drugs, 2, 1- 12, 1995.
94. Hall, I.H.,
Reynolds, D.I., Wong, O.T., Sood, A., Spielvogel, B.F., "The
Effects of Boron Derivative on Lipid Absorption from the Intestine
and on Bile Lipids and Bile Acids of Sprague Dawley Rats"
Metal Based Drugs, 2, 65- 72, 1995.
95. Karthikeyan,
S., Sood, A., Tomasz, J., Spielvogel, B.F., Hall, I.H., "Cytotoxicity
of Boron Containing Dipeptide Analogs" Amino Acids, 8,
323-335, 1995.
96. Chen, S. Y.,
Burnham, B.S., Spielvogel, B.F., Sood, A., Wyrick, S.D., Hall,
I.H., "Synthesis of Trimethylamine-[14C] Carboxyborane
and Trimethylamine-[14C] Carboxymethoxyborane and L1210 Leukemia
Cell Uptake" Applied Organometallic Chem., 10, 279-282,
1996.
97. Hall, I.H.,
Burnham, B.S., Elkins, A., Sood, A., Powell, W., Tomasz, J.,
Spielvogel, B.F., "Boronated Pyrimidines and Purines
as Cytotoxic, Hypolipidemic and Anti-Inflammatory Agents"
Metal Based Drugs, 3, 155-160, 1996.
98. Murphy, N.E.,
Elkins, A.L., Shrewsbury, R.P, Sood, A., Spielvogel, B.F.,
Hall, I.H., "The Effects of Amine-Carboxyborane Related
Derivatives on UMR-106 Bone Metabolism" Metal Based Drugs,
2, 31-47, 1996.
99. Burnham, B.S.,
Sood, A., Tomasz, J., Powell, W.J., Spielvogel, B.F., Chen,
S.Y., Hall, I.H., "The Hypolipidemic Activity of Boronated
Nucleosides in Male Mice and Rats" Metal Based Drugs,
3, 173-183, 1996.
100. Miller, M.C.
III, Sood, A., Spielvogel, B.F., Shrewsbury, R.P., Hall, I.H.,
"The Pharmacological Activities of the Metabolites of
N-[(Trimethylamineboryl)-Carbonyl]-L- Phenylalanine Methyl
Ester" Metal-Based Drugs, 3, 219-226, 1996.
101. Miller, M.C.
III, Sood, A., Spielvogel, B.F., Hall, I.H., "Effects
of Amine Carboxyborane Metal Complexes on L1210 DNA Topoisomerase
II” Research Communications in Pharmacology and Toxicology,
1, 245-268, 1996.
102. Spielvogel,
B.F., Powell, W., Sood, A., "The Chemical Basis for DNA
Diagnostics Using Boronated DNA" Main Group Metal Chemistry,
19, 699- 704, 1996.
103. Hall, I.H.,
Elkins, A., Sood, A., Tomasz, J., Spielvogel, B.F., "Boron
Substituted Deoxyribonucleosides as Cytotoxic Agents"
Anticancer Research, 16, 3709-3714, 1996.
104. Hall, I.H.,
Elkins, A.L., Karthikeyan, S., Spielvogel, B.F., "The
Cytotoxicity of 1- (Phenylmethyl)-4,7,10-tris-[(4'Methylphenyl)
Sulfonyl]-1,4,7,10-tetraazacyclododecane in Human Tmolt3 T
Leukemic Cells" Anticancer Research, 17, 1195-1198, 1997.
105. Hall, I.H.,
Elkins, A.L., Sood, A., Tomasz, J., Spielvogel, B.F., "The
Cytotoxicity of Adenosine 5'-[N,N-di-(y-o-carboranyl) propyl]
Phosphorodiamidate in Human Tmolt3 Leukemic Cells" Anticancer
Research, 17, 151-156, 1997.
106. Takagaki,
M., Ono, K., Masunaga, S., Kinashi, Y., Suzuki, M., Powell,
W., Sood, A., Spielvogel, B.F., "Borotrimethylglyclphenylanine
as Potential Boron Carrier for Boron Neutron Capture Therapy
on Malignant Brain Tumors: A Study on Human Glioma Cell Line"
Advances in Neutron Capture Therapy, Vol. II, Chemistry and
Biology, 491-496, Elsevier Press, Amsterdam, 1997.
107. Miller, M.C.
III, Sood, A., Spielvogel, B.F., Bastow, K., Hall, I.H., "Cytotoxic
Action of Carboxyborane Heterocyclic Amine Adducts" Metal
Based Drugs, 4, 229-241, 1997.
108. Hall, M.E.,
Shrewsbury, R.P., Chen, S.Y., Elkins, A.L., Burnham, B.S.,
Spielvogel, B.F., Hall, I.H., "The Disposition and Tissue
Distribution of Trimethylamine-(14C] Carboxyborane and Trimethylamine-(14C]
Carboxymethoxyborane in CF1 Mice" Pharmaceutical Sciences,
3, 473-478, 1997.
109. Miller, M.C.
III, Sood, A., Spielvogel, B.F., Hall, I.H., "Synthesis
and Antitumor Activity of Boronated Dipeptides Containing
Aromatic Amino Acids" Anticancer Research, 17, 3299-3306,
1997.
110. Miller, M.C.
III, Sood, A., Spielvogel, B.F., Hall, I.H., "The Synthesis
and Antitumor Activity of Metal Complexes of Amine-Carboxyborane
Adducts" Applied Organometallic Chemistry, Vol. 12, 87-97,
1998.
111. Miller, M.C.
III, Sood, A., Spielvogel, B.F., Hall, I.H., "The Synthesis
and Antitumor Activity of the Sodium Salt and Copper (II)
Complex of N-(Trimethylamineboryl)- Carbonyl]-L-Phenylalanine
Methyl Ester" Metal Based Drugs, Vol.5, 1-9, 1998.
112. Miller, M.C.
III, Woods, C.M., Murphy, M.E., Elkins, A., Spielvogel, B.F.,
Hall, I.H., "Relationship Between Amine-Carboxyboranes
and TNFa for the Regulation of Cell Growth in Different Tumor
Cell Lines" Biomed & Pharmacother, 52, 169-179, 1998.
113. Hall, I.H.,
Elkins, A., Powell, W.J., Karthikeyan, S., Sood, A., Spielvogel,
B.F., "Substituted Carboranes and Polyhedral Hydroborate
Salts as Anti-Neoplastics" Anticancer Research, 18, 2617-2622,
1998.
114. Miller, M.C.
III, Sood, A., Spielvogel, B.F., Hall, I.H., "Effects
of Alkyl Amine Carboxyboranes on L1210 DNA Fragmentation and
Nucleic Acid Metabolism" Arch Pharm., 331 (5), 153-162,
1998.
115. Miller, M.C.
III, Sood, A., Spielvogel, B.F., Hall, I.H., "The Hypolipidemic
and Anti- Inflammatory Activity of Boronated Aromatic Amino
Acids in CF1 Male Mice" Metal Based Drugs, Vol. 6, No.
6, 337-334, 1999.
116. Hosmane, N.S.,
Franken, A., Zhang, G., Srivastava, R.R. Smith, R.Y., Spielvogel,
B.F., "Synthesis and Crystal Structure of a Novel Fused
Polyhedral Borane Dianion, (B22H22]2- : Potential Precursor
for Use in Boron Neutron Capture Therapy (BNCT) of Cancer"
Main Group Metal Chemistry, 21, 319-324, 1999.
117. Takagaki,
M. Ono, K. Masunga, S., Kinashi, Y., Ona, Y., Miyatake, S.,
Hasimoto, N., Powell, W., Sood, A., Spielvogel, B.F., "Boronated
Dipeptide Borotrimethylglycinephenylalanine as a Potential
Boron Carrier in Boron Neutron Capture Therapy for Malignant
Brain Tumors" Radiation Research, 156, 118-122, 2001.
118. Tjarks, W.,
Wang, J., Chandra, S., Ji, W., Zhuo, C., Lunato, A.J., Cosquer,
G.Y., Eriksson, S., Morrison, G.H., Spielvogel, B.F., "Boronated
Nucleosides for BNCT" in press.
119. Zheng, C.,
Spielvogel, B.F., Smith, R., Hosmane, N.S., "Crystal
Structure of 4- Methylphenylboronic Acid: C7H9BO2”,
Z. Kristallogr. NCS 216, 341-342, 2001.
120. Vyakaranam,
K., Rana, G., Li, S., Zheng, C., Spielvogel, B.F., Hosmane,
N.S., "Crystal Structure of an Anti-neoplastic Agent.
Diethyl-N'- Methyl (Diisopropylphosphonate)Amine-Cyanoborane,
C9H22BN2O3P” Main Group Metal Chemistry, 24. No.11,
807-808, 2001.
121. Vyakaranam,
K., Zhang, H., Zheng, C., Li, S., Spielvogel, B.F. and Hosmane
N. S., "Crystal Structure of An Anti-Neoplastic Agent,
Diethyl-N-Methyl-N-(o- Carboranylmethyl) Phosphoramidate,
C8H26B10NO3P” Main Group Metal Chemistry 24, No.11,
809-810, 2001.
122. Vyakaranam,
K. Rana, G. Hosmane, N.S. Spielvogel, B.F., "New Boron
Analogues of Pyrophosphates and Deoxynucleoside Boranophosphates",
Metal Based Drugs, 8, Nr 3, 145-148, 2001.
123. Vyakaranam,
K. Rana, G. Spielvogel, B.F. Hosmane, N.S. "The First
Substituted Boranonucleic Acids: A Novel Synthetic Route"
Inorganic Chemistry Communications 4, 629-631, 2001.
124. Spielvogel,
B.F., Rana, G., Vyakaranam, K., McPhail, A.T., Ahmed, F.U.,
Hosmane, N.S., “A Novel Protonated Boranoamino Acid
Amide Derivative, (CH3)3N.BH2C(OH)=N+HC2H5Cl–: A Synthetic
and Structural Investigation”, Inorganic Chemistry Comm.
4, 336-338, 2001.
125. Geeta Rana,
Kamesh Vyakaranam, Hongming Zhang, Bernard F. Spielvogel,
and Narayan S. Hosmane, "Crystal structure of all anti-neoplastic
agent, piperazinecarboxyborane, C5H13BN2O2, Main Group Met.
Chem., 25, 169, 2002.
126. Kamesh Vyakaranam,
Geeta Rana, Chong Zheng, Shoujian Li, Bernard F. Spielvogel
and Narayan S. Hosmane, "Crystal structure of an anti-neoplastic
agent, 0- toluidinecyanoborane, C8H11BN2", Main Group
Met. Chem., 25, 171, 2002.
127. Kamesh Vyakaranam,
Geeta Rana, Chong Zheng, Shoujian Li, Bernard F. Spielvogel
and Narayan S. Hosmane, "Crystal structure of an anti-neoplastic
agent, morpholine-4- carboxyborane, C5H12BNO3", Main
Group Met. Chem., 25, 181, 2002.
128. Geeta Rana,
Kamesh Vyakaranam, Chong Zheng, Shoujian Li, Bernard F. Spielvogel,
and Narayan S. Hosmane, "Crystal structure of an anti-neoplastic
agent, 1- methylimidazole-3-(N-ethylcarbamoyl)borane, C7H14BN3O",
Main Group Met. Chem., 25, 179, 2002.
129. Kamesh Vyakaranam,
Geeta Rana, Shoujian Li, Chong Zheng, Bernard F. Spielvogel
and Narayan S. Hosmane, "Convenient One-Pot Synthesis
of Triphenylphosphinecarbomethoxyborane: Antitumor Activity
and Structural Investigation", Inorg. Chem. Comm., 5,
458, 2002.
130. Bernard F.
Spielvogel, Geeta Rana, Kamesh Vyakaranam, Kurt Grelck, Kari
E. Dicke, Bridget D. Dolash, Shoujian Li, Chong Zheng, John
A. Maguire, Masao Takagaki and Narayan S. Hosmane, "A
Novel Approach to the Syntheses of Functionalized, Water-
Soluble Icosahedral Carboranyl Anions. Crystal Structure of
N- [(Trimethylamineboryl)carbonyl]-L-tyrosinate: A Synthon
for Novel Carboranylpeptides", Collect. Czech. Chem.
Commun.,., 67, 1095, 2002.
131. Kamesh Vyakaranam,
Geeta Rana, Bernard F. Spielvogel and Narayan S. Hosmane,
"Synthesis of Novel Substituted Boranophosphate Nucleosides",
Nucleosides, Nucleotides and Nucleic Acids, 21, 581, 2002.
132. Geeta Rana,
Kamesh Vyakaranam, Chong Zheng, Shoujian Li, Bernard F. Spielvogel,
and Narayan S. Hosmane, "Crystal structure of an anti-neoplastic
agent, piperidinecarboxyborane, C6H14BNO2",Main Group
Met. Chem., 25, 107, 2002.
133. Kamesh Vyakaranam,
Geeta Rana, Kurt Grelck, Shoujian Li, Chong Zheng, Bernard
F. Spielvogel and Narayan S. Hosmane, "Synthetic, Spectroscopic
and Antitumor Activity Studies on Phosphacyanoboranes",
Inorg. Chim. Acta., 343C, 383, 2003.
134. Geeta Rana,
Kamesh Vyakaranam, Bernard F. Spielvogel, John A. Maguire
and Narayan S. Hosmane, "Novel Boron Analogues of pyrophosphates",
Inorg. Chim. Acta., 344C, 249, 2003.
135. Geeta Rana,
Kamesh Vyakaranam, Bernard F. Spielvogel, Shoujian Li, Chong
Zheng, John A. Maguire and Narayan S. Hosmane, "Synthesis
of Substituted-Borane Adducts of Amines and Amino Acids. The
Crystal Structure of Pyridine-N-ethylcarbamoylborane",
Inorg. Chim. Acta., 342, 255, 2003.
136. Kamesh Vyakaranam,
Geeta Rana, Bernard F. Spielvogel, John L. A. Mitchell, Shoujian
Li, Chong Zheng and Narayan S. Hosmane, "Synthesis and
Crystal Structure of 1,4-diaminobutyl-N, N'-bis(cyanoborane):
The First Substituted Borane Adduct of Putrescine" Inorg.
Chem. Comm., 5, 522, 2002.
137. Narayan S.
Hosmane, Luqman Adams, Jianhui Wang, Kamesh Vyakaranam, Geeta
Rana, Sumathy N. Hosmane, Bernard F. Spielvogel, and Jamey
E. Eklund, "From Boron-10 Enriched Boric Acid to BNCT
Drugs", In Research and Development in Neutron Capture
Therapy; Sauerwein, W., Moss, R., Wittig, A., Eds.; Monduzzi
(MEDIMOND, Inc.) Publ: Bologna, Italy;99-105, 2002.
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